AI, Biotech & Private Markets: Exclusive Insights from Wei Shen, Head of Principal Investment - Junson Capital
28 March 2025
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We spoke with Junson Capital’s Principal Investment Division to uncover their top investment strategies, market trends, and how family offices are reshaping venture and growth-stage investing. From the dominance of AI-native applications to the art of selecting top-tier fund managers, this deep dive reveals what it takes to thrive in today’s complex investment landscape.
As Junson Capital’s Principal Investment Division focuses on global technology and life sciences, what are the key trends you're currently seeing in these sectors?
The technology sector is currently defined by the widespread integration of AI. We anticipate that nearly all software companies will either incorporate AI tools in their workflows or develop their own AI products.
However, a significant number of these efforts may struggle to achieve commercial success. In the near future, AI-native applications are expected to dominate both enterprise and consumer markets. While many venture capitalists are focused on the software aspect of AI, we are equally enthusiastic about the hardware side, as smart devices will play a crucial role in capturing, processing, and acting on data.
In the life sciences sector, precision medicine and advanced tools are poised to remain key trends, with AI playing a pivotal role. As our understanding of molecular structures deepens, we can improve efficiency in target identification, drug design, and the flexibility of treatment modalities. We are optimistic that AI will significantly accelerate drug discovery and clinical trials in the future, enabling faster market entry for new therapies and reducing costs for biotech and pharmaceutical companies.
How do you balance early-stage venture investments with growth-stage opportunities?
Junson Capital primarily focuses on early-stage venture investments, particularly at the Series A and Series B stages. Our goal is to take an active role in collaborating with founders and other value-add investors to co-build companies. At these stages, most companies are transitioning platform technologies or sciences into market-ready products or are just beginning commercialization. Additionally, we reserve capital to support our portfolio companies as they scale into later stages to maximize our returns. In short, we adopt a proactive approach in early-stage investments and a more passive strategy for growth-stage opportunities.
In the current economic environment, how has your investment strategy evolved?
Investment thesis has been stable and top-down driven, but we definitely made necessary adjustments in executing an investment. In the current economic climate, we believe successful companies must possess both robust technological moats and a clear near-term path to commercialization. Technological moats establish the foundational value of a company, while early commercialization reduces reliance on external funding which has been volatile and unpredictable. This philosophy also extends to pre-revenue companies such as biotech. We encourage these companies to engage in asset licensing discussions early on to generate early liquidity. Additionally, we are crafting investment structures, such as milestone-based payments, protective terms, and management incentives, to better reward early-stage investors for taking on higher risks and to align long-term interests with the management team.
You manage over 40 portfolio companies—what are the key factors you consider when supporting and scaling these investments?
Our investment criteria include factors such as technological or scientific moats, the experience of the management team, product roadmap, market size, and more. While this framework is fairly standard and of little differentiation among most GPs, one unique and critical aspect of our deal evaluation is the management team’s problem-solving capabilities. Regardless of the stage, even the most promising companies will inevitably face challenges (financially, operationally, or strategically). A top-tier management team should be able to identify, analyze, and ultimately resolve these issues. Given this, we now dedicate significant time to assessing and observing founders’ problem-solving abilities during our diligence process.
Given your frequent dialogues with top-tier GPs, what qualities do you look for when selecting fund managers?
Beyond the many qualities that are widely agreed upon, we believe one of the most important attributes is consistency across a fund’s investment thesis, execution, and the GP’s expertise. This consistency ensures that what LPs invest in aligns with what they expect. For instance, we’ve seen GPs describe themselves as active investors in their portfolio companies, but they have no board representation or special shareholder rights. This raises inconsistency as such GPs have no strong levers to influence the companies. Another example is an alpha-driven GP that invests in hundreds of portfolios across multiple sectors, which is more likely to deliver beta returns to LPs. We believe top fund managers have a clear understanding of their strategy and possess the full capabilities to execute their investment thesis effectively.
How does being a single-family office investor shape your approach compared to institutional investors or multi-family offices?
Single-family offices benefit from a unique level of flexibility, which extends to the nature of our capital, investment strategies, management styles, and innovative partnership structures. Unlike traditional funds, which are often constrained by pre-set mandates or investment scopes, we have the freedom to adapt and tailor our approach. This flexibility allows us to support our portfolio companies in diverse ways, including equity investments, M&A financing, restructuring, human capital reorganizations, anchoring themed funds, SMAs, incubation, and buyouts. This broad toolkit enables us to act as a truly long-term, value-adding partner to our portfolio companies. We are committed to continuing to leverage this flexibility to enhance and expand our ecosystem.
What are the biggest challenges SFOs face in navigating private markets today?
Building a robust ecosystem is a long-term endeavor that requires dedicated effort, but it is crucial for SFOs. Given their typically smaller and leaner team setting, SFOs must rely on a strong network of partners to efficiently and effectively source and manage investments. Moreover, SFOs need to craft a compelling 'winning pitch' to attract top-tier companies and GPs by clearly articulating their unique value propositions and the resources they bring to the table. In today’s private markets, both companies and GPs are increasingly seeking value-adding partners who can actively contribute to their growth.
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One of the key messages from Junson Capital is to embrace AI’s transformative power while investing with discipline. The coming years promise greater integration of AI across industries, increased M&A activity, and the continued rise of family offices as standalone investment powerhouses.
For investors looking to navigate the ever-evolving venture space, the advice is clear: know your strengths and determine the unique value you bring to the table. By staying informed, strategic, and adaptable, investors can position themselves for long-term success in the private markets.
Join us at The World Family Office Forum | Europe Edition to gain deeper insights from industry leaders like Junson Capital and explore the future of private market investments.



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